🤖 OpenAI Launches Secure MCP Tunnels

🦾Plus: 💰 OpenAI Foundation puts $250M for Shared AI Prosperity

In partnership with

Hey folks! Let’s get into Big Data and AI craziness…

In today's edition: From a $250M fund for AI prosperity to a world model of protein biology — today’s digest spans the full spectrum: tools, research, capital, and hardware👇

  • 🤖Top 10 Applications of Artificial AI and ML You Should Know

  • 🔊On-Device TTS That Outperforms Cloud APIs

  • 🔄Every Software Just Became Agent-Native

  • ⚙️Microsoft SkillOpt: Train the Skill, Not the Model

  • 🧬 Biohub’s new ‘world model of protein biology’

  • 💡 AI Tutorial:How to build Android apps using Google AI Studio

  • 🤖AI Tools and Data Tools to checkout

Your private MCP servers can now stay inside your network while ChatGPT, Codex, and the Responses API connect through outbound-only HTTPS. No inbound ports, no public endpoints, no VPN. If you've been holding off on connecting internal tools to OpenAI products because of network security concerns, this removes that blocker.

When Did Your Business Start Running You?

What started as ownership turned into obligation.

Now you’re in every meeting, decision, and channel… not because you want to be, but because things stall without you.

It’s not a capacity issue. It’s a structure issue.

The Freedom Framework shows you how to rebuild work flows, so you can step back without things breaking down.

BELAY U.S.-based Assistants help make that real by bringing ownership to execution, so your business doesn’t rely on you to function.

Machine learning is a fragment of AI and a very significant one. It is a subset of AI that has proved to be successful for technology to make headway. Artificial intelligence is based on Computer Science, Biology, Psychology, Linguistics, Mathematics, and Engineering. It is the exploitation of computer functions that are related to human intelligence, such as reasoning, learning and problem-solving.

Most TTS systems make a tradeoff: quality requires the cloud. Supertonic skips that tradeoff entirely. It's a 66M parameter text-to-speech model that runs locally via ONNX Runtime, generates speech up to 167x faster than real-time, and beats ElevenLabs, OpenAI TTS-1, and Gemini on characters per second, without any network dependency.

CLI-Anything from the HKUDS lab fixes this by generating full CLI harnesses for any software, turning GUI-only apps into agent-controllable tools. One command analyzes the target app's source code, architects a CLI, implements it with tests, and publishes it to PATH. The project ships with a growing registry of 50+ ready-made CLIs covering GIMP, Blender, LibreOffice, OBS, Obsidian, Kdenlive, QGIS, and more.

SkillOpt from Microsoft Research does exactly that. Instead of fine-tuning model weights, it treats SKILL.md as a trainable external parameter. The frozen target model executes tasks, records scored trajectories, and a separate optimizer model proposes structured edits to the skill. Edits are accepted only when held-out validation performance improves.

Your best prompts are the ones you'd never bother typing.

The detailed ones. The ones with examples and edge cases. Wispr Flow lets you speak them instead — clean, structured, ready to paste into any AI tool. Free on Mac, Windows, and iPhone.

👨‍💻 Data Tools, Libraries

Cakework
Build serverless async backends without cloud resources.

DriftDB
A real-time data backend for browser-based applications.

Jampack
Optimizes static websites for best user experience and best Core Web Vitals scores.

Sintra: The AI "dream team" for overwhelmed operators. Access 12+ specialized agents that handle marketing, sales, ops, and much more for you - no prompting experience required.

AI News:

OpenAI Foundation, the nonprofit arm that owns 26% of OpenAI’s for-profit business, committed an initial $250M to fund grants, partnerships, and direct work helping workers, communities, and economies navigate AI-driven disruption. The funds will drive efforts to understand AI’s economic impact, support workers facing near-term disruption, and build long-term economic security.

One agent, one brain, zero manual work.

Most AI tools forget you the moment the chat ends. SureThing doesn’t.

SureThing is an autonomous agent that can draft in your voice, triage what matters, follow up on things you forgot, and report back with what happened next.

Day 1, you onboard it.
Day 30, it knows your clients and patterns.
Day 90, it catches things you missed.

Mark Zuckerberg and Priscilla Chan’s Biohub just released new Evolutionary Scale Models, creating an engine to map, predict, and design proteins — with the open system showing results against cancer and immune disease targets. The highlight is ESMFold2, a model built on a protein language model (ESMC) trained on 2.8B sequences to predict protein structure and design proteins.

Tesla's new Optimus factory is officially under construction at Gigafactory Texas. The project will add more than 5.2 million square feet of new industrial space. Tesla plans to build about 27,000 Optimus robots a day at the new factory. Production will start either in July or August of this year, with high-volume output starting in Summer 2027.

Amazon just killed off its AI shopping assistant Rufus and upgraded Alexa to fill its spot… and now it’s selling the feature to other retailers. In a blog post today, the tech leader said the new service will allow retailers to launch their own AI shopping tools tailored to their storefront, catalog, and branding “in as little as 60 days.”

When Sam Altman comes a callin’… ServiceNow’s Chief Marketing Officer Colin Fleming announced that he’s departing the software company to join OpenAI as CMO of its business unit. The executive spent two years at ServiceNow following 13 years at SalesForce in their Product and Global Marketing divisions.

AI Tutorial

How to build Android apps using Google AI Studio

You don’t need to know how to code to build a simple Android app. You can use Google AI Studio to describe the app you want, test it in your browser, and keep editing it with simple prompts. Here is how:

  1. Go to Google AI Studio and sign in with your Google account.

  2. Click “Build” or start a new app project.

  3. Choose the Android app option from the drop-down menu

  4. Describe the app you want to build & let AI Studio build it.

  5. Test the app in the browser using the Android emulator.

  6. If something is wrong, type what you want to change.

  7. You can also test the app on a real Android phone before sharing it.

  8. When you are done, download the project as a ZIP file, send it to GitHub, or keep working on it in Android Studio.

Dive into the AI Toolkits for Entrepreneurs, a hand-picked collection designed to help you grow your business:

80+ Curated AI Tools for Entrepreneurs 🛠️

10 Financial AI Tools 💰

Bonus Content: 250 Entrepreneurial Prompts

🔥Top AI tools to increase productivity: 

  1. AirRankPilot helps local businesses get discovered by Google and AI tools like ChatGPT and Perplexity

  2. InboxKit is your all-in-one platform for building, managing, and scaling cold-email infrastructure.

  3. CCPayment is a cryptocurrency payment platform allowing merchants to accept and payouts

  4. HuePress is a SaaS platform providing therapy-grade, high-quality printable coloring pages

  5. Creatives Takeover is an AI  platform that turns raw founder ideas into business plans

  6. Pixelexact AI image generator composing scenes on fixed canvases

  7. Reelbase - Create Viral TikTok Slideshows in Seconds

  8. Qeeebo is an AI-curated question-and-answer platform built with a clear and ambitious purpose

View our database of all the best AI tools for your needs: aitoolsup.com

Have cool resources to share? Submit AI tool

A.I. Generated Image of the Day

👀 A colossal kraken.

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